منابع مشابه
Two open states of P2X receptor channels
The occupancy of the orthosteric ligand binding sites of P2X receptor (P2XR) channels causes the rapid opening of a small cation-permeable pore, followed by a gradual dilation that renders the pore permeable to large organic cations. Electrophysiologically, this phenomenon was shown using whole-cell current recording on P2X2R-, P2X2/X5R-, P2X4R- and P2X7R-expressing cells that were bathed in N-...
متن کاملActivation and regulation of purinergic P2X receptor channels.
Mammalian ATP-gated nonselective cation channels (P2XRs) can be composed of seven possible subunits, denoted P2X1 to P2X7. Each subunit contains a large ectodomain, two transmembrane domains, and intracellular N and C termini. Functional P2XRs are organized as homomeric and heteromeric trimers. This review focuses on the binding sites involved in the activation (orthosteric) and regulation (all...
متن کاملPost-translational regulation of P2X receptor channels: modulation by phospholipids
P2X receptor channels mediate fast excitatory signaling by ATP and play major roles in sensory transduction, neuro-immune communication and inflammatory response. P2X receptors constitute a gene family of calcium-permeable ATP-gated cation channels therefore the regulation of P2X signaling is critical for both membrane potential and intracellular calcium homeostasis. Phosphoinositides (PIPn) ar...
متن کاملATP-gated P2X channels
What are they? P2X channels are a family of cell-membrane cation channels which open within milliseconds of binding ATP. They are distinct from the other family of ATP receptors, the G-proteincoupled P2Y receptors, and also from other transmitter-gated ion channels. P2X channels are the third major family of mammalian transmitter-gated ion channels (Figure 1); they are similar in topology to am...
متن کاملPore-opening mechanism in trimeric P2X receptor channels
The kidney is extraordinarily sensitive to adverse fetal programming. Malnutrition, the most common form of developmental challenge, retards the formation of functional units, the nephrons. The resulting low nephron endowment increases susceptibility to renal injury and disease. Using explanted rat embryonic kidneys, we found that ouabain, the Na,K-ATPase ligand, triggers a calcium-nuclear fact...
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ژورنال
عنوان ژورنال: Frontiers in Human Neuroscience
سال: 2013
ISSN: 1662-5161
DOI: 10.3389/fncel.2013.00215